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OCR: secretion Children may have insufficiency of GH as a result from birth or may acquire it later, either (rarely) of a tumour in the area of the monly) hypothalamus or pituitary or (more com secondary to cranial irradiation. h deletion A congenital deficiency may arise throug which is of the GH gene. Congenital insufficiency usually the commonly encountered condition, i ndary to a associated with pituitary hypoplasia seco g hormonedeficiency of the secretion of GH-releasir from the hypothalamus, sufficiency The difference between deficiency and in her have is important since children with the forr holecule no immunological tolerance to the GH r ed to and thus develop antibodies when expo therapy